ID: 8 y/o female with acute gastroenteritis prescribed ceftriaxone and ondansetron (with 2 doses already given).
- Based on a quick literature search, I found that ondansetron is only indicated for 1 dose for acute gastroenteritis.
- I also found an association of antibiotic use with certain strains of gastroenteritis (E. coli O157:H7), which can cause hemolytic uremic syndrome when treated with antibiotics.
- Since gastroenteritis is most commonly viral, antibiotic therapy is inappropriate and presents a concern with regards to antimicrobial stewardship.
These issues were discussed with the pediatrician, and we were able to discontinue both medication orders! This was an exciting opportunity to clarify the medication order, because the physician was very open and amenable to listening to the pharmacy perspective. Moreover, it allowed me to advocate for the best interest of my patient which is always a great component of pharmaceutical care.